RAPID COMMUNICATION Involvement of Interleukin-3 in Delayed-Type Hypersensitivity
نویسندگان
چکیده
The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3–deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell– dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity. r 1998 by The American Society of Hematology.
منابع مشابه
Involvement of interleukin-3 in delayed-type hypersensitivity.
The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findi...
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